Hello there! I'm Pradyumna Harlapur, a PhD student in the Cancer Systems Biology Lab at Indian Institute of Science, Bengaluru. As someone deeply passionate about biology, I've always marveled at the intricate complexity of biological systems and their abilility to seamlessly carry out myriad of tasks with precision, robustness, and coordination. Specifically, my research focuses on studying the network of interactions between genes driving cellular decision making and uncovering the underlying design principles that govern these interactions within gene regulatory networks (GRNs). When not getting lost in the labyrinth of my code trying to untangle these biological puzzles, I enjoy reading science fiction and fantasy novels, observing the tiny wonders of the insect world, ricing my system, and going on treks. If you're curious about what I get out of days spent on untangling the cryptic rules of biological networks, feel free to explore my research and projects!

[Publications] [Awards and Fellowships] [Teaching] [Conferences]

Publications

Published

  1. GRiNS: a python library for simulating gene regulatory network dynamics.
    Pradyumna Harlapur, Harshavardhan BV and Mohit Kumar Jolly (2025). BMC Bioinformatics 26, 250 (2025). DOI: 10.1186/s12859-025-06268-0
  2. Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks
    Pradyumna Harlapur*, Kishore Hari*, Aashna Saxena*, Kushal Haldar, Aishwarya Girish, Tanisha Malpani, Herbert Levine, Mohit Kumar Jolly (2025). iScience, Volume 28, Issue 2 (2025). DOI: 10.1016/j.isci.2024.111730
  3. Immune digital twins for complex human pathologies: applications, limitations, and challenges.
    Niarakis, A., Laubenbacher, R., An, G. ..., Pradyumna Harlapur, ..., et al (2024). npj Systems Biology and Applications 10, 141. DOI: 10.1038/s41540-024-00450-5
  4. Dynamics of T-helper cell differentiation and plasticity: How have computational models improved our understanding?
    Pradyumna Harlapur, Atchuta Srinivas Duddu, Mohit Kumar Jolly (2024). Current Opinion in Systems Biology 37, 100508. DOI: 10.1016/j.coisb.2024.100508
  5. Synthetic Gene Circuits Combining CRISPR Interference and CRISPR Activation in E. coli: Importance of Equal Guide RNA Binding Affinities to Avoid Context-Dependent Effects.
    Içvara Barbier, Hadiastri Kusumawardhani, Lakshya Chauhan, Pradyumna Harlapur, Mohit Kumar Jolly, Yolanda Schaerli (2023). ACS Synthetic Biology 12 (10), 3064-3071. DOI: 10.1021/acssynbio.3c00375
  6. Functional Resilience of Mutually Repressing Motifs Embedded in Larger Networks.
    Pradyumna Harlapur, Atchuta Srinivas Duddu, Kishore Hari, Prakash Kulkarni, Mohit Kumar Jolly (2022). Biomolecules, 12(12), 1842. DOI: 10.3390/biom12121842
  7. Emergent properties of coupled bistable switches.
    Pradyumna Harlapur*, Kishore Hari*, Aditi Gopalan, Varun Ullanat, Atchuta Srinivas Duddu, Mohit Kumar Jolly (2022). J Biosci (2022) 47:81. DOI: 10.1007/s12038-022-00310-6

Awards and Fellowships

Awards

Fellowships

Teaching

Param Hansa Centre for Computational Oncology (PHCCO) Summer Training Programme. May to July 2024.

Biological Systems Modelling: Advanced Techniques. April 2024: Link

Introduction to Systems Biology. August to October 2023: Link

Conferences